Colorful Greek island harbor on a sunny Mediterranean coast

Mediterranean / 7 nights

Greek Isles and Eastern Mediterranean

A classic first Mediterranean cruise: start in Rome, sail to Santorini, visit Ephesus through Kusadasi, spend time in Mykonos and finish with Naples or Capri before returning to Civitavecchia.

Sample
Sample verified sailing: June 7-14, 2026
Line
Royal Caribbean
Ship
Odyssey of the Seas

Route rhythm

How the week usually flows

  1. Day 1

    Rome (Civitavecchia), Italy

    Embark near Rome, with time for a pre-cruise city stay if flights allow.

    • Colosseum
    • Vatican area
    • Trastevere
    • Civitavecchia train link
  2. Day 2

    At sea

    A full ship day for pools, dining, shows and activity reservations.

    • SeaPlex
    • North Star
    • Two70
    • pool deck
  3. Day 3

    Santorini, Greece

    Tender port known for cliff villages, caldera views, black-sand beaches and sunset stays on many sailings.

    • Oia
    • Fira
    • caldera viewpoints
    • Akrotiri
  4. Day 4

    Ephesus (Kusadasi), Turkey

    A gateway to Ephesus, the Celsus Library area and the Temple of Artemis site.

    • Ephesus ruins
    • Celsus Library
    • House of the Virgin Mary
    • Kusadasi bazaar
  5. Day 5

    Mykonos, Greece

    Windmills, beaches, white lanes and lively waterfront dining.

    • Mykonos windmills
    • Little Venice
    • Hora lanes
    • beach clubs
  6. Day 6

    At sea

    A reset day before Italy, good for speciality dining or a theatre night.

    • speciality dining
    • spa
    • live music
    • adult casino venue
  7. Day 7

    Naples/Capri, Italy

    Easy access to pizza in Naples, Pompeii, Sorrento, Capri and the Amalfi Coast.

    • Pompeii
    • Capri
    • Sorrento
    • Naples historic center
  8. Day 8

    Rome (Civitavecchia), Italy

    Early arrival for onward travel.

    • airport transfers
    • post-cruise Rome stay

Who offers this style

Cruise companies and ships to compare

Royal Caribbean

Verified representative 2026 sailing from Rome.

  • Odyssey of the Seas

Norwegian Cruise Line

Often offers Greek Isles programs from Athens, Rome or Venice-area ports.

  • Norwegian Viva
  • Norwegian Pearl

Celebrity Cruises

Premium Mediterranean and Greek Isles programs vary by season.

  • Celebrity Ascent
  • Celebrity Eclipse

Destination Notes

  • Santorini and Mykonos can be busy in peak months, so early shore plans matter.
  • Tender ports depend on weather and local operations.
  • Ephesus is hot in summer; comfortable shoes, water and shade breaks are practical essentials.

Planning Notes

  • Use this route when you want famous Greek islands without packing and unpacking.
  • Rome departures are convenient for pre- or post-cruise city days.
  • Always verify port times with the cruise line before booking flights or independent tours.

Adult Casino Context

Many mainstream cruise ships include a physical onboard casino. Access is adult-only and depends on the cruise line, ship and itinerary.

Read the casino entertainment guide

Sources Checked